| http://purl.uniprot.org/citations/36330957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36330957 | http://www.w3.org/2000/01/rdf-schema#comment | "Increasing studies have revealed that a subset of circular RNAs (circRNAs) harbor an open reading frame and can act as protein-coding templates to generate functional proteins that are closely associated with multiple physiological and disease-relevant processes, and thus proper regulation of synthesis of these circRNA-derived proteins is a fundamental cellular process required for homeostasis maintenance. However, how circRNA translation initiation is coordinated by different trans-acting factors remains poorly understood. In particular, the impact of different eukaryotic translation initiation factors (eIFs) on circRNA translation and the physiological relevance of this distinct regulation have not yet been characterized. In this study, we screened all 43 Drosophila eIFs and revealed the conflicting functions of eIF3 subunits in the translational control of the translatable circRNA circSfl: eIF3 is indispensable for circSfl translation, while the eIF3-associated factor eIF3j is the most potent inhibitor. Mechanistically, the binding of eIF3j to circSfl promotes the disassociation of eIF3. The C-terminus of eIF3j and an RNA regulon within the circSfl untranslated region (UTR) are essential for the inhibitory effect of eIF3j. Moreover, we revealed the physiological relevance of eIF3j-mediated circSfl translation repression in response to heat shock. Finally, additional translatable circRNAs were identified to be similarly regulated in an eIF3j-dependent manner. Altogether, our study provides a significant insight into the field of cap-independent translational regulation and undiscovered functions of eIF3."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkac980"xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Ji Y."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Jia R."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Song Z."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Su R."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/author | "Shan G."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/pages | "11529-11549"xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/title | "eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/36330957 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36330957 |
| http://purl.uniprot.org/citations/36330957 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36330957 |
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| http://purl.uniprot.org/uniprot/#_Q0E940-mappedCitation-36330957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36330957 |