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http://purl.uniprot.org/citations/36332016http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36332016http://www.w3.org/2000/01/rdf-schema#comment"Two fundamental elements of pre-implantation embryogenesis are cells' intrinsic self-organization program and their developmental plasticity, which allows embryos to compensate for alterations in cell position and number; yet, these elements are still poorly understood. To be able to decipher these features, we established culture conditions that enable the two fates of blastocysts' extraembryonic lineages-the primitive endoderm and the trophectoderm-to coexist. This plasticity emerges following the mechanisms of the first lineage segregation in the mouse embryo, and it manifests as an extended potential for extraembryonic chimerism during the pre-implantation embryogenesis. Moreover, this shared state enables robust assembly into higher-order blastocyst-like structures, thus combining both the cell fate plasticity and self-organization features of the early extraembryonic lineages."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.org/dc/terms/identifier"doi:10.1126/sciadv.abl9583"xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Brinkmann H."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Chen R."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Kim Y.S."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Fan R."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Kim K.P."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Stehling M."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Jeong H.W."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Adams R.H."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Vaquerizas J.M."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Scholer H.R."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Bedzhov I."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Ing-Simmons E."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Sathyanarayanan A."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Ozguldez H.O."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/author"Duethorn B."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/name"Sci Adv"xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/pages"eabl9583"xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/title"Early developmental plasticity enables the induction of an intermediate extraembryonic cell state."xsd:string
http://purl.uniprot.org/citations/36332016http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/36332016http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/36332016
http://purl.uniprot.org/citations/36332016http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/36332016