| http://purl.uniprot.org/citations/36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36335117 | http://www.w3.org/2000/01/rdf-schema#comment | "The assembly of mammalian SWI/SNF chromatin remodeling complexes is developmentally programed, and loss/mutations of SWI/SNF subunits alter the levels of other components through proteolysis, causing cancers. Here, we show that mouse Lsd1/Kdm1a deletion causes dramatic dissolution of SWI/SNF complexes and that LSD1 demethylates the methylated lysine residues in SMARCC1 and SMARCC2 to preserve the structural integrity of SWI/SNF complexes. The methylated SMARCC1/SMARCC2 are targeted for proteolysis by L3MBTL3 and the CRL4DCAF5 ubiquitin ligase complex. We identify SMARCC1 as the critical target of LSD1 and L3MBTL3 to maintain the pluripotency and self-renewal of embryonic stem cells. L3MBTL3 also regulates SMARCC1/SMARCC2 proteolysis induced by the loss of SWI/SNF subunits. Consistently, mouse L3mbtl3 deletion causes striking accumulation of SWI/SNF components, associated with embryonic lethality. Our studies reveal that the assembly/disassembly of SWI/SNF complexes is dynamically controlled by a lysine-methylation dependent proteolytic mechanism to maintain the integrity of the SWI/SNF complexes."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-34348-9"xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Sun H."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Guo P."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Sanchez J."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Hoang N."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Zhang E.H."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Trinidad K."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/author | "Rajawasam K."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/pages | "6696"xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/title | "The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis."xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36335117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36335117 |
| http://purl.uniprot.org/citations/36335117 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36335117 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J170-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_D3YYF2-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_D3YYG4-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_D3Z1M8-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_D3Z1N4-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_D3Z1W6-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |
| http://purl.uniprot.org/uniprot/#_E9Q7L2-mappedCitation-36335117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36335117 |