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| http://purl.uniprot.org/citations/3633923 | http://www.w3.org/2000/01/rdf-schema#comment | "A physical DNA binding assay was employed to analyze the binding of yeast RNA polymerase III transcription factor C (TFIIIC) to tRNA genes. The assay allowed us to measure the equilibrium constants for specific and nonspecific TFIIIC-DNA binding and to assess the effects of tRNATyr-DNA gene promoter mutations on binding. Sequence alterations in the B block element of the promoter greatly affect the equilibrium constant for specific TFIIIC binding (K8). Mutations which decrease tRNATyr homology to the recognized B block consensus sequence drastically reduce K8 (43-to 370-fold), while mutations which increase homology increase K8 (4-to 5-fold). By contrast, point mutations in the A block element of the tRNATyr promoter have less than 2-fold effects on K8; however, total deletion of A block sequences reduces K8 2-to 5-fold. These results indicate that TFIIIC-rTNA gene binding involves interactions with both A block and B block sequences, but B block interactions dominate, and the relative contribution of A block interactions is small. Since A block sequences are absolutely required for active tRNA gene transcription, the binding results suggest that the role of A block sequences in transcription is not confined solely to TFIIIC binding."xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)57210-6"xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/author | "Hall B.D."xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/author | "Baker R.E."xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/author | "Gabrielsen O."xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/pages | "5275-5282"xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/title | "Effects of tRNATyr point mutations on the binding of yeast RNA polymerase III transcription factor C."xsd:string |
| http://purl.uniprot.org/citations/3633923 | http://purl.uniprot.org/core/volume | "261"xsd:string |
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