| http://purl.uniprot.org/citations/36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36343253 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic diseases. As a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) transcription factor family, NPAS4 is distinguished by an ability to form functional heterodimers with aryl hydrocarbon receptor nuclear translocator (ARNT) and ARNT2, both of which are also bHLH-PAS family members. Here, we describe the quaternary architectures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers in complexes involving DNA response elements. Our crystallographic studies reveal a uniquely interconnected domain conformation for the NPAS4 protein itself, as well as its differentially configured heterodimeric arrangements with both ARNT and ARNT2. Notably, the PAS-A domains of ARNT and ARNT2 exhibit variable conformations within these two heterodimers. The ARNT PAS-A domain also forms a set of interfaces with the PAS-A and PAS-B domains of NPAS4, different from those previously noted in ARNT heterodimers formed with other class I bHLH-PAS family proteins. Our structural observations together with biochemical and cell-based interrogations of these NPAS4 heterodimers provide molecular glimpses of the NPAS4 protein architecture and extend the known repertoire of heterodimerization patterns within the bHLH-PAS family. The PAS-B domains of NPAS4, ARNT, and ARNT2 all contain ligand-accessible pockets with appropriate volumes required for small-molecule binding. Given NPAS4's linkage to human diseases, the direct visualization of these PAS domains and the further understanding of their relative positioning and interconnections within the NPAS4-ARNT and NPAS4-ARNT2 heterodimers may provide a road map for therapeutic discovery targeting these complexes."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2208804119"xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Zhuang J."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Rastinejad F."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Diao X."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/author | "Jing L."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/pages | "e2208804119"xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/title | "Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family."xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/36343253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36343253 |
| http://purl.uniprot.org/citations/36343253 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36343253 |
| http://purl.uniprot.org/uniprot/#_P53762-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_Q86TN1-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_Q8BGD7-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_Q8IUM7-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_Q9HBZ2-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_Q61324-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |
| http://purl.uniprot.org/uniprot/#_X5D7T2-mappedCitation-36343253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36343253 |