| http://purl.uniprot.org/citations/36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36361568 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymph node metastasis is associated with poor prognosis of oral squamous cell carcinoma (OSCC), and few studies have explored the relevance of postoperative lymphatic drainage (PLD) in metastatic OSCC. Alpha-enolase (ENO1) is a metabolic enzyme, which is related to lymphatic metastasis of OSCC. However, the role of ENO1 in PLD in metastatic OSCC has not been elucidated. Herein, we collected lymphatic drainage after lymphadenectomy between metastatic and non-metastatic lymph nodes in OSCC patients to investigate the relationship between ENO1 expression and metastasis, and to identify the proteins which interacted with ENO1 in PLD of patients with metastatic OSCC by MS/GST pulldown assay. Results revealed that the metabolic protein apolipoprotein C-III (ApoC3) was a novel partner of ENO1. The ENO1 bound to ApoC3 in OSCC cells and elicited the production of interleukin (IL)-8, as demonstrated through a cytokine antibody assay. We also studied the function of IL-8 on Jurkat T cells co-cultured with OSCC cells in vitro. Western blot analysis was applied to quantitate STAT3 (signal transducer and activator of transcription 3) and p-STAT3 levels. Mechanistically, OSCC cells activated the STAT3 signaling pathway on Jurkat T cells through IL-8 secretion, promoted apoptosis, and inhibited the proliferation of Jurkat T cells. Collectively, these findings illuminate the molecular mechanisms underlying the function of ENO1 in metastasis OSCC and provide new strategies for targeting ENO1 for OSCC treatment."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms232112777"xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Bu L."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Zhong N."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/author | "Man Q."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/pages | "12777"xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/title | "ENO1 Binds to ApoC3 and Impairs the Proliferation of T Cells via IL-8/STAT3 Pathway in OSCC."xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/36361568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36361568 |
| http://purl.uniprot.org/citations/36361568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36361568 |
| http://purl.uniprot.org/uniprot/#_A0A024R4F1-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_E2DRY6-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_A3KPE2-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |
| http://purl.uniprot.org/uniprot/#_A4UCS8-mappedCitation-36361568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36361568 |