| http://purl.uniprot.org/citations/36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36373462 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-1β can exit the cytosol as an exosomal cargo following inflammasome activation in intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)-dependent manner. The mechanistic connection linking inflammasome activation and the biogenesis of exosomes has so far remained largely elusive. Here, we report the Ras GTPase-activating-like protein IQGAP1 functions as an adaptor, bridging GSDMD to the endosomal sorting complexes required for transport (ESCRT) machinery to promote the biogenesis of pro-IL-1β-containing exosomes in response to NLPR3 inflammasome activation. We identified IQGAP1 as a GSDMD-interacting protein through a non-biased proteomic analysis. Functional investigation indicated the IQGAP1-GSDMD interaction is required for LPS and ATP-induced exosome release. Further analysis revealed that IQGAP1 serves as an adaptor which bridges GSDMD and associated IL-1β complex to Tsg101, a component of the ESCRT complex, and enables the packaging of GSDMD and IL-1β into exosomes. Importantly, this process is dependent on an LPS-induced increase in GTP-bound CDC42, a small GTPase known to activate IQGAP1. Taken together, this study reveals IQGAP1 as a link between inflammasome activation and GSDMD-dependent, ESCRT-mediated exosomal release of IL-1β."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.org/dc/terms/identifier | "doi:10.15252/embj.2022110780"xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Liao Y."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Willard B."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Bulek K."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/author | "Miller-Little W."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/pages | "e110780"xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/title | "The Ras GTPase-activating-like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL-1beta release via exosomes."xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/36373462 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36373462 |
| http://purl.uniprot.org/citations/36373462 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPI2-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNG5-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPU3-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VKQ7-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A2R8W727-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_A0A679AXP3-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |
| http://purl.uniprot.org/uniprot/#_Q05CQ4-mappedCitation-36373462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36373462 |