| http://purl.uniprot.org/citations/36376304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36376304 | http://www.w3.org/2000/01/rdf-schema#comment | "C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display unexpected discordant effects between the shared traits which are translated into discordant associations with clinical outcomes in subsequent phenome-wide association studies. Our findings provide insights into shared mechanisms underlying inflammation and lipid metabolism, representing potential preventive and therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-34688-6"xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Dehghan A."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Elliott P."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Said S."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Boyle J.J."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Evangelou E."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Tzoulaki I."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/author | "Koskeridis F."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/pages | "6939"xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/title | "Pleiotropic genetic architecture and novel loci for C-reactive protein levels."xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36376304 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36376304 |
| http://purl.uniprot.org/citations/36376304 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36376304 |
| http://purl.uniprot.org/uniprot/#_C9JRE9-mappedCitation-36376304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36376304 |
| http://purl.uniprot.org/uniprot/#_P02741-mappedCitation-36376304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36376304 |
| http://purl.uniprot.org/uniprot/C9JRE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36376304 |
| http://purl.uniprot.org/uniprot/P02741 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36376304 |