| http://purl.uniprot.org/citations/36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36383412 | http://www.w3.org/2000/01/rdf-schema#comment | "Human prostate cancer can result from chromosomal rearrangements that lead to aberrant ETS gene expression. The mechanisms that lead to fusion-independent ETS factor upregulation and prostate oncogenesis remain relatively unknown. Here, we show that two neighboring transcription factors, Capicua (CIC) and ETS2 repressor factor (ERF), which are co-deleted in human prostate tumors can drive prostate oncogenesis. Concurrent CIC and ERF loss commonly occur through focal genomic deletions at chromosome 19q13.2. Mechanistically, CIC and ERF co-bind the proximal regulatory element and mutually repress the ETS transcription factor, ETV1. Targeting ETV1 in CIC and ERF-deficient prostate cancer limits tumor growth. Thus, we have uncovered a fusion-independent mode of ETS transcriptional activation defined by concurrent loss of CIC and ERF."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.77072"xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Gupta N."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Small E.J."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Lin Y.K."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Huang F.W."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Feng F.Y."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Okimoto R.A."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/author | "Ponce R.K."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/pages | "e77072"xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/title | "The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression."xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/36383412 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36383412 |
| http://purl.uniprot.org/citations/36383412 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36383412 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQR4-mappedCitation-36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383412 |
| http://purl.uniprot.org/uniprot/#_A0A7P0T9K5-mappedCitation-36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383412 |
| http://purl.uniprot.org/uniprot/#_B7Z6N1-mappedCitation-36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383412 |
| http://purl.uniprot.org/uniprot/#_P50548-mappedCitation-36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383412 |
| http://purl.uniprot.org/uniprot/#_Q96RK0-mappedCitation-36383412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383412 |