| http://purl.uniprot.org/citations/36383655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36383655 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate immunity is the first line of host defense against pathogens. Here, through global transcriptome and proteome analyses, we uncover that newly described cytoplasmic poly(A) polymerase TENT-5 (terminal nucleotidyltransferase 5) enhances the expression of secreted innate immunity effector proteins in Caenorhabditis elegans. Direct RNA sequencing revealed that multiple mRNAs with signal peptide-encoding sequences have shorter poly(A) tails in tent-5-deficient worms. Those mRNAs are translated at the endoplasmic reticulum where a fraction of TENT-5 is present, implying that they represent its direct substrates. Loss of tent-5 makes worms more susceptible to bacterial infection. Notably, the role of TENT-5 in innate immunity is evolutionarily conserved. Its orthologs, TENT5A and TENT5C, are expressed in macrophages and induced during their activation. Analysis of macrophages devoid of TENT5A/C revealed their role in the regulation of secreted proteins involved in defense response. In summary, our study reveals cytoplasmic polyadenylation to be a previously unknown component of the posttranscriptional regulation of innate immunity in animals."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.org/dc/terms/identifier | "doi:10.1126/sciadv.add9468"xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Dziembowski A."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Ewbank J.J."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Wegierski T."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Cysewski D."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Liudkovska V."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Mroczek S."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Drabikowski K."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Krawczyk P.S."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Guminska N."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Mackiewicz Z."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/author | "Brouze A."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/name | "Sci Adv"xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/pages | "eadd9468"xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/title | "TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals."xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/36383655 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36383655 |
| http://purl.uniprot.org/citations/36383655 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36383655 |
| http://purl.uniprot.org/uniprot/#_A0A087WS27-mappedCitation-36383655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383655 |
| http://purl.uniprot.org/uniprot/#_D3Z5S8-mappedCitation-36383655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383655 |
| http://purl.uniprot.org/uniprot/#_Q3V3I9-mappedCitation-36383655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383655 |
| http://purl.uniprot.org/uniprot/#_Q5SSF7-mappedCitation-36383655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36383655 |