| http://purl.uniprot.org/citations/36394541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36394541 | http://www.w3.org/2000/01/rdf-schema#comment | "Mammalian sperm-egg adhesion depends on the trans-interaction between the sperm-specific type I glycoprotein IZUMO1 and its oocyte-specific GPI-anchored receptor JUNO. However, the mechanisms and proteins (fusogens) that mediate the following step of gamete fusion remain unknown. Using live imaging and content mixing assays in a heterologous system and structure-guided mutagenesis, we unveil an unexpected function for IZUMO1 in cell-to-cell fusion. We show that IZUMO1 alone is sufficient to induce fusion, and that this ability is retained in a mutant unable to bind JUNO. On the other hand, a triple mutation in exposed aromatic residues prevents this fusogenic activity without impairing JUNO interaction. Our findings suggest a second function for IZUMO1 as a unilateral mouse gamete fusogen."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.202207147"xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Higashiyama T."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Brukman N.G."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Flyak K."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Podbilewicz B."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Valansi C."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/author | "Nakajima K.P."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/pages | "e202207147"xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/title | "A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion."xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://purl.uniprot.org/core/volume | "222"xsd:string |
| http://purl.uniprot.org/citations/36394541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36394541 |
| http://purl.uniprot.org/citations/36394541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36394541 |
| http://purl.uniprot.org/uniprot/#_Q9D9J7-mappedCitation-36394541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36394541 |
| http://purl.uniprot.org/uniprot/Q9D9J7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36394541 |