| http://purl.uniprot.org/citations/36396934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36396934 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic glycogen is the main source of blood glucose and controls the intervals between meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared to their adult counterparts; however, the detailed molecular mechanism is poorly understood. Here, we show that, similar to glycogen storage pattern, N6-methyladenosine (m6A) modification in mRNAs gradually increases during the growth of mice in liver. Strikingly, in the hepatocyte-specific Mettl3 knockout mice, loss of m6A modification disrupts liver glycogen storage. On the mechanism, mRNA of Gys2, the liver-specific glycogen synthase, is a substrate of METTL3 and plays a critical role in m6A-mediated glycogenesis. Furthermore, IGF2BP2, a "reader" protein of m6A, stabilizes the mRNA of Gys2. More importantly, reconstitution of GYS2 almost rescues liver glycogenesis in Mettl3-cKO mice. Collectively, a METTL3-IGF2BP2-GYS2 axis, in which METTL3 and IGF2BP2 regulate glycogenesis as "writer" and "reader" proteins respectively, is essential on maintenance of liver glycogenesis in mammals."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-022-34808-2"xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Cheng S."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Yang A."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/author | "Zhang X.'"xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/pages | "7038"xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/title | "N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA."xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/36396934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36396934 |
| http://purl.uniprot.org/citations/36396934 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36396934 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVR4-mappedCitation-36396934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36396934 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J041-mappedCitation-36396934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36396934 |