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http://purl.uniprot.org/citations/36401616http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36401616http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36401616http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Pathogenic variants in genes encoding ubiquitin E3 ligases are known to cause neurodevelopmental syndromes. Additional neurodevelopmental disorders associated with the other genes encoding E3 ligases are yet to be identified.

Methods

Chromosomal analysis and exome sequencing were used to identify the genetic causes in 10 patients from 7 unrelated families with syndromic neurodevelopmental, seizure, and movement disorders and neurobehavioral phenotypes.

Results

In total, 4 patients were found to have 3 different homozygous loss-of-function (LoF) variants, and 3 patients had 4 compound heterozygous missense variants in the candidate E3 ligase gene, HECTD4, that were rare, absent from controls as homozygous, and predicted to be deleterious in silico. In 3 patients from 2 families with Angelman-like syndrome, paralog-directed candidate gene approach detected 2 LoF variants in the other candidate E3 ligase gene, UBE3C, a paralog of the Angelman syndrome E3 ligase gene, UBE3A. The RNA studies in 4 patients with LoF variants in HECTD4 and UBE3C provided evidence for the LoF effect.

Conclusion

HECTD4 and UBE3C are novel biallelic rare disease genes, expand the association of the other HECT E3 ligase group with neurodevelopmental syndromes, and could explain some of the missing heritability in patients with a suggestive clinical diagnosis of Angelman syndrome."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.org/dc/terms/identifier"doi:10.1016/j.gim.2022.10.006"xsd:string
http://purl.uniprot.org/citations/36401616http://purl.org/dc/terms/identifier"doi:10.1016/j.gim.2022.10.006"xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Lupski J.R."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Lupski J.R."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Pastore A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Pastore A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Alfadhel M."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Alfadhel M."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Bonneau D."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Bonneau D."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Colin E."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Colin E."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Nigro V."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Nigro V."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Torella A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Torella A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Alghamdi M.A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Alghamdi M.A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Bertoli-Avella A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Bertoli-Avella A."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Karageorgou V."xsd:string
http://purl.uniprot.org/citations/36401616http://purl.uniprot.org/core/author"Karageorgou V."xsd:string
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