| http://purl.uniprot.org/citations/36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36403479 | http://www.w3.org/2000/01/rdf-schema#comment | "The influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells was investigated. HCC cells were transfected with siRNA and lentivirus to achieve SOS1 knock down/overexpression and changes in RNA and protein levels analyzed by q-PCR and Western blotting (WB). Transwell assay was utilized to assess variations in cell invasion and migration in vitro and by a lung metastasis model of liver cancer in vivo. High expression of SOS1 was observed in most human liver cancers, which indicated a worse prognosis. SOS1 knockout in HepG2 cells significantly decreased cell invasion and migration. SOS1 knockout also reduced the number of metastatic foci in a lung metastasis model of HCC established in nude mice. SOS1 knockout inhibited the epithelial-mesenchymal transition (EMT) in HepG2 cells as well as the PI3K/AKT/mTOR pathway. Overexpression of SOS1 in Huh7 cells had the opposite effect. To conclude, SOS1 may induce the EMT by the activation of the PI3K/AKT/mTOR pathway, thereby enhancing invasion, migration and metastasis of HCC cells. These findings may expose SOS1 as a new HCC therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2022.11.015"xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/author | "Yin Y."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/author | "He K."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/pages | "161-169"xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/title | "SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway."xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://purl.uniprot.org/core/volume | "637"xsd:string |
| http://purl.uniprot.org/citations/36403479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36403479 |
| http://purl.uniprot.org/citations/36403479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36403479 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SG47-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_G5E9C8-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_Q53SF8-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_Q59GG9-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_Q9UKX9-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/#_Q8NIA3-mappedCitation-36403479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/Q59GG9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/Q8NIA3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36403479 |
| http://purl.uniprot.org/uniprot/G5E9C8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36403479 |