| http://purl.uniprot.org/citations/36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36404922 | http://www.w3.org/2000/01/rdf-schema#comment | "Some Parkinson's disease (PD)-causative/risk genes, including the PD-associated kinase leucine-rich repeat kinase 2 (LRRK2), are involved in membrane dynamics. Although LRRK2 and other PD-associated genes are believed to regulate synaptic functions, axonal transport, and endolysosomal activity, it remains unclear whether a common pathological pathway exists. Here, we report that the loss of Lrrk, an ortholog of human LRRK2, leads to the accumulation of the lysosome-related organelle regulator, Arl8 along with dense core vesicles at the most distal boutons of the neuron terminals in Drosophila. Moreover, the inactivation of a small GTPase Rab3 and altered Auxilin activity phenocopied Arl8 accumulation. The accumulation of Arl8-positive vesicles is UNC-104-dependent and modulated by PD-associated genes, Auxilin, VPS35, RME-8, and INPP5F, indicating that VPS35, RME-8, and INPP5F are upstream regulators of Lrrk. These results indicate that certain PD-related genes, along with LRRK2, drive precise neuroaxonal transport of dense core vesicles."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2022.105476"xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Ishii R."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Liu J.Y."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Hattori N."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Inoshita T."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Shiba-Fukushima K."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/author | "Taniguchi D."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/pages | "105476"xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/title | "Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/36404922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36404922 |
| http://purl.uniprot.org/citations/36404922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG14-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHT3-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF57-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF91-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEY0-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_A0A0S0X7U5-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_E1JHJ9-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |
| http://purl.uniprot.org/uniprot/#_E1JHK0-mappedCitation-36404922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36404922 |