| http://purl.uniprot.org/citations/36424637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36424637 | http://www.w3.org/2000/01/rdf-schema#comment | "Siglec-15, a novel immune suppressor, is upregulated in many human cancers. The aim of this study was to explore the expression of Siglec-15 in colorectal cancer (CRC), and investigate whether Siglec-15 could be a potential target for cancer immunotherapy in patients with CRC. We performed immunohistochemical analyses of Siglec-15 on a cohort of 805 patients with CRC and made comparisons between clinicopathological characteristics, PD-L1 expression, CD3, CD8, CD45RO tumor-infiltrating lymphocytes (TILs), and prognosis. We found that Siglec-15 expression was commonly detected in tumor cells (48.3%) and tumor-associated stromal cells (33.4%), and was more frequently observed than PD-L1 expression in tumor cells. In contrast, Siglec-15 expression was weakly and scarcely found in normal mucosa (13%). Siglec-15 overexpression in tumor cells was associated with advanced TNM stage (p = 0.020). Co-expression of Siglec-15 and PD-L1 in tumor cells was found in 14.4% of patients, and Siglec-15 expression was detected in almost half of PD-L1 negative cases. Elevated Siglec-15 expression in tumor and stromal cells was associated with sparser CD45RO and CD8 TILs (p = 0.035 and p = 0.004, respectively). The expression of Siglec-15 did not have prognostic significance. In summary, compared to PD-L1, Siglec-15 protein expression is more prevalent in CRC and is associated with advanced disease stage and fewer TILs. These findings support Siglec-15 as a potential cancer immunotherapy target, in addition to PD-1/PD-L1 inhibitors, in patients with CRC."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.org/dc/terms/identifier | "doi:10.1002/cjp2.303"xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Lu Z."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Peng C."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Huang F."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Cheng P."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/author | "Zou S."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/name | "J Pathol Clin Res"xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/pages | "121-128"xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/title | "Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/36424637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36424637 |
| http://purl.uniprot.org/citations/36424637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36424637 |
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| http://purl.uniprot.org/uniprot/#_Q6ZMC9-mappedCitation-36424637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36424637 |
| http://purl.uniprot.org/uniprot/A7E1W7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36424637 |
| http://purl.uniprot.org/uniprot/Q6ZMC9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36424637 |