| http://purl.uniprot.org/citations/36430689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36430689 | http://www.w3.org/2000/01/rdf-schema#comment | "The rapid growth and division of cancer cells are associated with mitochondrial biogenesis or switching to glycolysis. ERRα, PGC-1α and irisin/FNDC5 are some of the proteins that can influence these processes. The aim of this study was to determine the correlation of these proteins in non-small cell lung cancer (NSCLC) and to investigate their association with clinicopathological parameters. Immunohistochemistry reactions were performed on tissue microarrays (860 NSCLC, 140 non-malignant lung tissue). The normal fibroblast cell line (IMR-90) and lung cancer cell lines (NCI-H1703 and NCI-H522) were used as co-cultures. The mRNA levels of FNDC5 and ESRRA (encoding ERRα) were assessed in IMR-90 cells after co-culture with lung cancer cells. We observed a decreased level of ERRα with an increase in tumor size (T), stages of the disease, and lymph node metastases (N). In the adenocarcinoma (AC) subtype, patients with a higher ERRα expression had significantly longer overall survival. A moderate positive correlation was observed between FNDC5 mRNA and ESRRA mRNA in NSCLCs. The expression of FNDC5 mRNA in IMR-90 cells increased after 24 h, and ESRRA gene expression increased after 48 h of co-culture. The ERRα receptor with PGC-1α participates in the control of FNDC5/irisin expression. Normal fibroblasts revealed an upregulation of the FNDC5 and ESRRA genes under the influence of lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms232214204"xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Jablonska K."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Dziegiel P."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Podhorska-Okolow M."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Piotrowska A."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Nowinska K."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Ciesielska U."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Pawelczyk K."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/author | "Haczkiewicz-Lesniak K."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/pages | "14204"xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/title | "Association of Irisin/FNDC5 with ERRalpha and PGC-1alpha Expression in NSCLC."xsd:string |
| http://purl.uniprot.org/citations/36430689 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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