| http://purl.uniprot.org/citations/36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36437414 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA) class I subunit expression level in primary and metastatic lesions has been characterized in many cancer types utilizing formalin-fixed and paraffin-embedded (FFPE) tissue sections as substrates in immunohistochemical reactions. The evaluation of the results of these studies has been hampered by the scant information about HLA class I subunit expression level in normal tissues. To address this unmet need, we have analyzed the HLA class I subunit expression level in FFPE sections of normal tissues.Two tissue microarray (TMA) blocks were constructed from archived FFPE tissue samples of a wide number of human normal tissues. The expression level of HLA-A, HLA-B, HLA-C heavy chains and β2-microglobulin (β2-M) was evaluated by IHC staining, with mAb HC-A2, mAb HC-10, and mAb NAMB1, respectively. The staining was scored according to its intensity.According to their staining patterns with the three mAbs tested, normal tissues can be divided into four groups: (i) tissues displaying moderate/strong staining patterns, (ii) tissues displaying barely detectable staining patterns, (iii) tissues displaying differential staining patterns, and (iv) tissues with no detectable staining. The ubiquitous expression pattern for HLA-A, B, C heavy chain and β2-M was found only at the endothelial level; the stroma was negative except for fibroblasts in all the tissues analyzed. Our data suggest that, contrary to the general postulate, HLA class I subunit expression is not detectable in all nucleated cells. This information provides a useful background to evaluate changes in HLA class I subunit expression associated with the malignant transformation of cells."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00428-022-03459-5"xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Ferrone S."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Massi D."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Mandala M."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Baroni G."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Nesi G."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Szumera-Cieckiewicz A."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/author | "Ugolini F."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/name | "Virchows Arch"xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/pages | "359-368"xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/title | "Differential HLA class I subunit (A, B, C heavy chain and betapisub>2pi/sub>-microglobulin) expression levels in normal tissues."xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://purl.uniprot.org/core/volume | "482"xsd:string |
| http://purl.uniprot.org/citations/36437414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36437414 |
| http://purl.uniprot.org/citations/36437414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C553-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-36437414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36437414 |