| http://purl.uniprot.org/citations/36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36440630 | http://www.w3.org/2000/01/rdf-schema#comment | "Apical constriction powers amnioserosa contraction during Drosophila dorsal closure. The nucleation, movement and dispersal of apicomedial actomyosin complexes generates pulsed apical constrictions during early closure. Persistent apicomedial and circumapical actomyosin complexes drive unpulsed constrictions that follow. Here, we show that the microtubule end-binding proteins EB1 and Patronin pattern constriction dynamics and contraction kinetics by coordinating the balance of actomyosin forces in the apical plane. We find that microtubule growth from moving Patronin platforms governs the spatiotemporal dynamics of apicomedial myosin through the regulation of RhoGTPase signaling by transient EB1-RhoGEF2 interactions. We uncover the dynamic reorganization of a subset of short non-centrosomally nucleated apical microtubules that surround the coalescing apicomedial myosin complex, trail behind it as it moves and disperse as the complex dissolves. We demonstrate that apical microtubule reorganization is sensitive to Patronin levels. Microtubule depolymerization compromised apical myosin enrichment and altered constriction dynamics. Together, our findings uncover the importance of reorganization of an intact apical microtubule meshwork, by moving Patronin platforms and growing microtubule ends, in enabling the spatiotemporal modulation of actomyosin contractility and, through it, apical constriction."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.199759"xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/author | "Sharma D."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/author | "Saravanan S."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/author | "Narasimha M."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/author | "Guru A."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/pages | "dev199759"xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/title | "The microtubule end-binding proteins EB1 and Patronin modulate the spatiotemporal dynamics of myosin and pattern pulsed apical constriction."xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/36440630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36440630 |
| http://purl.uniprot.org/citations/36440630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFU3-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KET5-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEY4-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEY6-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFA4-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFF8-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_E1JH90-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_E1JH91-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7T7-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHJ5-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG58-mappedCitation-36440630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36440630 |