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| http://purl.uniprot.org/citations/36442092 | http://www.w3.org/2000/01/rdf-schema#comment | "We reconstructed the structure of actin filament branch junctions formed by fission yeast Arp2/3 complex at 3.5 Å resolution from images collected by electron cryo-microscopy. During specimen preparation, all of the actin subunits and Arp3 hydrolyzed their bound adenosine triphosphate (ATP) and dissociated the γ-phosphate, but Arp2 retained the γ-phosphate. Binding tightly to the side of the mother filament and nucleating the daughter filament growing as a branch requires Arp2/3 complex to undergo a dramatic conformational change where two blocks of structure rotate relative to each other about 25° to align Arp2 and Arp3 as the first two subunits in the branch. During branch formation, Arp2/3 complex acquires more than 8,000 Å2 of new buried surface, accounting for the stability of the branch. Inactive Arp2/3 complex binds only transiently to the side of an actin filament, because its conformation allows only a subset of the interactions found in the branch junction."xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2206722119"xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/author | "Pollard T.D."xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/author | "Chatterjee M."xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/author | "Chou S.Z."xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
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| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/title | "Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structureof the branch junction."xsd:string |
| http://purl.uniprot.org/citations/36442092 | http://purl.uniprot.org/core/volume | "119"xsd:string |
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