| http://purl.uniprot.org/citations/36450258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36450258 | http://www.w3.org/2000/01/rdf-schema#comment | "The precise regulation of synaptic connectivity and function is essential to maintain neuronal circuits. Here, we show that the Drosophila pseudo-kinase Madm/NRBP1 (Mlf-1-adapter-molecule/nuclear-receptor-binding protein 1) is required presynaptically to maintain synaptic stability and to coordinate synaptic growth and function. Presynaptic Madm mediates these functions by controlling cap-dependent translation via the target of rapamycin (TOR) effector 4E-BP/Thor (eukaryotic initiation factor 4E binding protein/Thor). Strikingly, at degenerating neuromuscular synapses, postsynaptic Madm induces a compensatory, transsynaptic signal that utilizes the presynaptic homeostatic potentiation (PHP) machinery to offset synaptic release deficits and to delay synaptic degeneration. Madm is not required for canonical PHP but induces a neurodegeneration-specific form of PHP and acts via the regulation of the cap-dependent translation regulators 4E-BP/Thor and S6-kinase. Consistently, postsynaptic induction of canonical PHP or TOR activation can compensate for postsynaptic Madm to alleviate functional and structural synaptic defects. Our results provide insights into the molecular mechanisms underlying neurodegeneration-induced PHP with potential neurotherapeutic applications."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.111710"xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Kins S."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Mushtaq Z."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Pielage J."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Aavula K."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Kieweg I.D."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Lasser D.A."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/author | "Lion L.M."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/pages | "111710"xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/title | "Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation."xsd:string |
| http://purl.uniprot.org/citations/36450258 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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