| http://purl.uniprot.org/citations/36468795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36468795 | http://www.w3.org/2000/01/rdf-schema#comment | "In Sertoli cells of the testis, cadherins (Cdh) are important cell-to-cell interaction proteins and contribute to the formation of the blood-testis barrier being essential for germ cells' protection. P-cadherin or Cdh3 is only expressed in Sertoli cells from embryonic to prepubertal development. Interestingly, the expression profile of Cdh3 correlates with that of activating protein-1 (AP-1) transcription factors during Sertoli cells development. To assess their potential implications in the regulation of Cdh3, different AP-1 transcription factors were overexpressed in 15P-1 Sertoli cells. We found that the overexpressions of Junb and Fosl2 activated Cdh3 promoter. ChIP-qPCR assay and luciferase reporter assay with 5' promoter deletions and site-directed mutagenesis confirmed the recruitment of Junb and Fosl2 to an AP-1 regulatory element at -47 bp in the proximal region of Cdh3 promoter in 15P-1 cells. These findings were further supported by histone modification markers and chromatin accessibility surrounding Cdh3 promoter in mouse testis. Moreover, the knockdowns of Junb and/or Fosl2 by siRNA decreased Cdh3 protein levels. Taken together, these data suggest that in 15P-1 Sertoli cells, the AP-1 family members Junb and Fosl2 are responsible for the regulation of Cdh3 expression, which requires the recruitment of both factors to the proximal region of the Cdh3 promoter."xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.org/dc/terms/identifier | "doi:10.1002/mrd.23656"xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/author | "Nguyen H.T."xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/author | "Martin L.J."xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/name | "Mol Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/pages | "27-41"xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/title | "The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells."xsd:string |
| http://purl.uniprot.org/citations/36468795 | http://purl.uniprot.org/core/volume | "90"xsd:string |
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