| http://purl.uniprot.org/citations/36473935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36473935 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent clinical research has revealed that mechanical ventilation (MV) can initiate pulmonary fibrosis and induce mechanical ventilation-induced pulmonary fibrosis (MVPF). However, the underlying mechanism remains largely uncharacterized. Based on a mouse model of MVPF and an alveolar epithelial cell cyclic strain model, the present study explores the possible mechanism of MVPF. Single-cell RNA-sequencing and EV RNA-sequencing analysis revealed that MV promoted apoptosis signal-regulating kinase 1 (ASK1)-mediated endoplasmic reticulum (ER) stress pathway activation and extracellular vesicle (EV) release from alveolar epithelial cells. Furthermore, the ASK1-ER stress pathway was shown to mediate mechanical stretch (MS)- or MV-induced EV release and lung fibroblast activation in vivo and in vitro. These processes were suppressed by ER stress inhibitors or by silencing ASK1 with ASK1-short hairpin RNA (shRNA). In addition, MVPF was suppressed by inhibiting ASK1 and ER stress in vivo. Therefore, the present study demonstrates that ASK1-ER stress pathway-mediated fibrotic-EV release from alveolar epithelial cells contributes to fibroblast activation and the initiation of pulmonary fibrosis during MV. The inhibited release of EVs targeting the ASK1-ER stress pathway might be a promising treatment strategy for MVPF."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.org/dc/terms/identifier | "doi:10.1038/s12276-022-00901-1"xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "He Z."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Tang R."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Mei S."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/author | "Xing S."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/pages | "2162-2174"xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/title | "ASK1-ER stress pathway-mediated fibrotic-EV release contributes to the interaction of alveolar epithelial cells and lung fibroblasts to promote mechanical ventilation-induced pulmonary fibrosis."xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/36473935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36473935 |
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