| http://purl.uniprot.org/citations/36477533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36477533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36477533 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis (for example, ankylosing spondylitis (AS)) and the eye (that is, acute anterior uveitis (AAU))1. How HLA-B*27 facilitates disease remains unknown, but one possible mechanism could involve presentation of pathogenic peptides to CD8+ T cells. Here we isolated orphan T cell receptors (TCRs) expressing a disease-associated public β-chain variable region-complementary-determining region 3β (BV9-CDR3β) motif2-4 from blood and synovial fluid T cells from individuals with AS and from the eye in individuals with AAU. These TCRs showed consistent α-chain variable region (AV21) chain pairing and were clonally expanded in the joint and eye. We used HLA-B*27:05 yeast display peptide libraries to identify shared self-peptides and microbial peptides that activated the AS- and AAU-derived TCRs. Structural analysis revealed that TCR cross-reactivity for peptide-MHC was rooted in a shared binding motif present in both self-antigens and microbial antigens that engages the BV9-CDR3β TCRs. These findings support the hypothesis that microbial antigens and self-antigens could play a pathogenic role in HLA-B*27-associated disease."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-022-05501-7"xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41586-022-05501-7"xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Bowness P."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Bowness P."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Fernandes R.A."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Fernandes R.A."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Jude K.M."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Jude K.M."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Yokoyama W.M."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Yokoyama W.M."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Garner L.I."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Garner L.I."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Brackenridge S."xsd:string |
| http://purl.uniprot.org/citations/36477533 | http://purl.uniprot.org/core/author | "Brackenridge S."xsd:string |