| http://purl.uniprot.org/citations/36484822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36484822 | http://www.w3.org/2000/01/rdf-schema#comment | "LncRNA H19 serves as a regulatory RNA in mouse placental development. However, there is little information available on the in situ expression of H19 in the late-gestation mouse placenta. In this study, we performed quantitative polymerase chain reaction (qPCR) and in situ hybridization (ISH) analyses of lncRNA H19 and its exon 1-derived miRNA miR-675-3p to identify cell types expressing these non-coding RNAs in the mouse placenta during mid-to-late gestation. By qPCR analysis, we confirmed that H19 was highly expressed during mid-to-late gestation (E10.5-E18.5) and that H19-derived miRNA miR-675-3p was remarkably upregulated in the E18.5 placenta. ISH analysis revealed trophoblast cell type-specific expression of lncRNA H19 and miR-675-3p during later stages of gestation. In the junctional zone and decidua of late-gestation placenta, H19 was expressed in trophoblast giant cells and glycogen trophoblast cells; however, H19 was absent in spongiotrophoblast cells. In the labyrinth and chorionic plate, H19 was present in sinusoidal mononuclear trophoblast giant cells, fetal vascular endothelial cells, and basal chorionic trophoblast cells, but not in syncytiotrophoblasts. As expected, these lncRNA H19-expressing cells exhibited miR-675-3p in the E18.5 placenta. Intriguingly, miR-675-3p was also present in H19-negative spongiotrophoblast cells and syncytiotrophoblasts, implying the possible transfer of miR-675-3p from H19-exprssing cells to adjacent H19-non-expressing trophoblast cells. These findings suggest that the mouse placenta expresses lncRNA H19 in a trophoblast cell type-specific fashion during later stages of gestation."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00418-022-02169-y"xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/author | "Sakurai T."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/author | "Takizawa T."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/author | "Takizawa T.'"xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/author | "Naing B.T."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/author | "Kyi-Tha-Thu C."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/name | "Histochem Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/pages | "363-375"xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/title | "Possible transfer of lncRNA H19-derived miRNA miR-675-3p to adjacent H19-non-expressing trophoblast cells in near-term mouse placenta."xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://purl.uniprot.org/core/volume | "159"xsd:string |
| http://purl.uniprot.org/citations/36484822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36484822 |
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