| http://purl.uniprot.org/citations/36493777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36493777 | http://www.w3.org/2000/01/rdf-schema#comment | "Following acute genotoxic stress, both normal and tumorous stem cells can undergo cell-cycle arrest to avoid apoptosis and later re-enter the cell cycle to regenerate daughter cells. However, the mechanism of protective, reversible proliferative arrest, "quiescence," remains unresolved. Here, we show that mitophagy is a prerequisite for reversible quiescence in both irradiated Drosophila germline stem cells (GSCs) and human induced pluripotent stem cells (hiPSCs). In GSCs, mitofission (Drp1) or mitophagy (Pink1/Parkin) genes are essential to enter quiescence, whereas mitochondrial biogenesis (PGC1α) or fusion (Mfn2) genes are crucial for exiting quiescence. Furthermore, mitophagy-dependent quiescence lies downstream of mTOR- and PRC2-mediated repression and relies on the mitochondrial pool of cyclin E. Mitophagy-dependent reduction of cyclin E in GSCs and in hiPSCs during mTOR inhibition prevents the usual G1/S transition, pushing the cells toward reversible quiescence (G0). This alternative method of G1/S control may present new opportunities for therapeutic purposes."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2022.11.004"xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Dang J."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Mathieu J."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Brewer D."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Harper S."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Ruohola-Baker H."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Lyons S."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Chan T.C."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Nguyen B.N."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Hussein A.M."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Ishibashi J.R."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Taslim T.H."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Keshri R."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Castillo D.D."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Balachandar N."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Garver B."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/author | "Jhajharia S."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/pages | "269-288"xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/title | "Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs."xsd:string |
| http://purl.uniprot.org/citations/36493777 | http://purl.uniprot.org/core/volume | "18"xsd:string |