| http://purl.uniprot.org/citations/36499416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36499416 | http://www.w3.org/2000/01/rdf-schema#comment | "SMILE (small heterodimer partner-interacting leucine zipper protein) is a transcriptional corepressor that potently regulates various cellular processes such as metabolism and growth in numerous tissues. However, its regulatory role in skin tissue remains uncharacterized. Here, we demonstrated that SMILE expression markedly decreased in human melanoma biopsy specimens and was inversely correlated with that of microphthalmia-associated transcription factor (MITF). During melanogenesis, α-melanocyte-stimulating hormone (α-MSH) induction of MITF was mediated by a decrease in SMILE expression in B16F10 mouse melanoma cells. Mechanistically, SMILE was regulated by α-MSH/cAMP/protein kinase A signaling and suppressed MITF promoter activity via corepressing transcriptional activity of the cAMP response element-binding protein. Moreover, SMILE overexpression significantly reduced α-MSH-induced MITF and melanogenic genes, thereby inhibiting melanin production in melanocytes. Conversely, SMILE inhibition increased the transcription of melanogenic genes and melanin contents. These results indicate that SMILE is a downstream effector of cAMP-mediated signaling and is a critical factor in the regulation of melanogenic transcription; in addition, they suggest a potential role of SMILE as a corepressor in skin pigmentation."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms232315094"xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Lee Y.S."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Kim D.K."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Choi H.S."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Moon C."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Jeon T.I."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Nguyen T.T.P."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/author | "Truong X.T."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/pages | "15094"xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/title | "SMILE Downregulation during Melanogenesis Induces MITF Transcription in B16F10 Cells."xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/36499416 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36499416 |
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| http://purl.uniprot.org/uniprot/#_E9PIM0-mappedCitation-36499416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36499416 |
| http://purl.uniprot.org/uniprot/#_A0A8F9W6H4-mappedCitation-36499416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36499416 |
| http://purl.uniprot.org/uniprot/#_A0A0A7NWS7-mappedCitation-36499416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36499416 |
| http://purl.uniprot.org/uniprot/#_B4DNC7-mappedCitation-36499416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36499416 |