| http://purl.uniprot.org/citations/36502418 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36502418 | http://www.w3.org/2000/01/rdf-schema#comment | "The reactivation of astrocytes plays a critical role in spinal cord injury (SCI) repairment. In this study, IL1RAP expression has been found to be upregulated in SCI mice spinal cord, SCI astrocytes, and LPS-stimulated NHAs. Genes correlated with IL1RAP were significantly enriched in cell proliferation relative pathways. In LPS-stimulated NHAs, IL1RAP overexpression promoted NHA cell proliferation, decreased PTEN protein levels, and increased the phosphorylation of Akt and mTOR. IL1RAP overexpression promoted LPS-induced NHA activation and NF-κB signaling activation. Conditioned medium from IL1RAP-overexpressing NHAs inhibited SH-SY5Y cells viability but promoted cell apoptosis. Conclusively, IL1RAP knockdown in LPS-stimulated NHAs could partially suppress LPS-induced reactive astrogliosis, therefore promoting neuronal cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11064-022-03811-w"xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Zhang K."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/author | "Xiang W."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/name | "Neurochem Res"xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/pages | "1468-1479"xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/title | "IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation."xsd:string |
| http://purl.uniprot.org/citations/36502418 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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