| http://purl.uniprot.org/citations/36534085 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36534085 | http://www.w3.org/2000/01/rdf-schema#comment | "Late cardiac toxicity is a potentially lethal complication of cancer therapy, yet the pathogenic mechanism remains largely unknown, and few treatment options exist. Here we report DNA-damaging agents such as radiation and anthracycline chemotherapies inducing delayed cardiac inflammation following therapy due to activation of cGAS- and STING-dependent type I interferon signaling. Genetic ablation of cGAS-STING signaling in mice inhibits DNA damage-induced cardiac inflammation, rescues late cardiac functional decline, and prevents death from cardiac events. Treatment with a STING antagonist suppresses cardiac interferon signaling following DNA-damaging therapies and effectively mitigates cardiac toxicity. These results identify a therapeutically targetable, pathogenic mechanism for one of the most vexing treatment-related toxicities in cancer survivors."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20220809"xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Socci N.D."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Chavez V."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Schmitt A.M."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Bakhoum S.F."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Liu J.E."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Patel S.H."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Chan A.T."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Adnan M."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Piersigilli A."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Yu A.F."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Shamseddine A."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Oeffinger K.C."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Dang C.T."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Moore Z.R."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Steingart R.M."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Di Bona M."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/author | "Ramanathan L.V."xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/pages | "e20220809"xsd:string |
| http://purl.uniprot.org/citations/36534085 | http://purl.uniprot.org/core/title | "Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies."xsd:string |