| http://purl.uniprot.org/citations/36537238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36537238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36537238 | http://www.w3.org/2000/01/rdf-schema#comment | "Disruptive mutations in the chromodomain helicase DNA-binding protein 8 gene (CHD8) have been recurrently associated with autism spectrum disorders (ASDs). Here we investigated how chromatin reacts to CHD8 suppression by analyzing a panel of histone modifications in induced pluripotent stem cell-derived neural progenitors. CHD8 suppression led to significant reduction (47.82%) in histone H3K36me3 peaks at gene bodies, particularly impacting on transcriptional elongation chromatin states. H3K36me3 reduction specifically affects highly expressed, CHD8-bound genes and correlates with altered alternative splicing patterns of 462 genes implicated in 'regulation of RNA splicing' and 'mRNA catabolic process'. Mass spectrometry analysis uncovered a novel interaction between CHD8 and the splicing regulator heterogeneous nuclear ribonucleoprotein L (hnRNPL), providing the first mechanistic insights to explain the CHD8 suppression-derived splicing phenotype, partly implicating SETD2, a H3K36me3 methyltransferase. In summary, our results point toward broad molecular consequences of CHD8 suppression, entailing altered histone deposition/maintenance and RNA processing regulation as important regulatory processes in ASD."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkac1134"xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkac1134"xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Di Leva F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Di Leva F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Gustincich S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Gustincich S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Piazza S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Piazza S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Gusella J.F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Gusella J.F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Campos E."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Campos E."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Benelli M."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Benelli M."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Ferrari F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Ferrari F."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Erdin S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Erdin S."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Talkowski M.E."xsd:string |
| http://purl.uniprot.org/citations/36537238 | http://purl.uniprot.org/core/author | "Talkowski M.E."xsd:string |