| http://purl.uniprot.org/citations/36543168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36543168 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial cells remodel cell adhesion and change their neighbors to shape a tissue. This cellular rearrangement proceeds in three steps: the shrinkage of a junction, exchange of junctions, and elongation of the newly generated junction. Herein, by combining live imaging and physical modeling, we showed that the formation of myosin-II (myo-II) cables around the cell vertices underlies the exchange of junctions in the Drosophila wing epithelium. The local and transient detachment of myo-II from the cell cortex is regulated by the LIM domain-containing protein Jub and the tricellular septate junction protein M6. Moreover, we found that M6 shifts to the adherens junction plane on jub RNAi and that Jub is persistently retained at reconnecting junctions in m6 RNAi cells. This interplay between Jub and M6 can depend on the junction length and thereby couples the detachment of cortical myo-II cables and the shrinkage/elongation of the junction during cell rearrangement. Furthermore, we developed a mechanical model based on the wetting theory and clarified how the physical properties of myo-II cables are integrated with the junction geometry to induce the transition between the attached and detached states and support the unidirectionality of cell rearrangement. Collectively, this study elucidates the orchestration of geometry, mechanics, and signaling for exchanging junctions."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2022.11.067"xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/author | "Sugimura K."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/author | "Ishihara S."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/author | "Tamori Y."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/author | "Ikawa K."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/pages | "263-275.e4"xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/title | "Attachment and detachment of cortical myosin regulates cell junction exchange during cell rearrangement in the Drosophila wing epithelium."xsd:string |
| http://purl.uniprot.org/citations/36543168 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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