| http://purl.uniprot.org/citations/36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36543308 | http://www.w3.org/2000/01/rdf-schema#comment | "Optimizing prognostic stratification of patients with cytogenetic normal acute myeloid leukemia (CN-AML), a highly heterogeneous subgroup in AML, appears to be important to improve its treatment and clinical outcome. Here, we report a potential role of ELL, a gene associated with leukemogenesis in AML, in prognostic stratification of CN-AML patients. By analyzing public available databases, we found that ELL was highly expressed in AML patients compared with healthy donors. Kaplan-Meier analysis revealed that ELL expression markedly correlated with short overall survival (OS) of CN-AML patients. In COX multivariable regression analysis, higher ELL expression was an independent prognostic factor for OS in CN-AML. Knockdown of ELL by shRNAs sensitized KG-1α cells to anti-leukemic agents such as idarubicin (IDA) and chidamide (CS055), supporting its role in therapeutic response and outcome in AML. To understand its function in CN-AML, we further analyzed the ELL-driving gene signature. ELL-related genes were particularly enriched in cell adhesion molecules, cell differentiation, pathways in cancer, sequence-specific DNA binding, and extracellular matrix (ECM)-receptor interaction. Analysis of the PPI network identified 25 hub genes, including the stem cell gene BMP4. While BMP4 expression was significantly associated with ELL in CN-AML, knockdown of ELL markedly down-regulated BMP4 expression, suggesting that ELL might function via regulating BMP4 in AML. Together, these observations suggest a novel mechanism underlying pro-leukemogenic role of ELL via BMP4 up-regulation in AML and its potential value to serve as a predictive biomarker for therapeutic response and outcome of CN-AML patients."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2022.147110"xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Pan G."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Tan J."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Xu B."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Zhong M."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Lai Q."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/author | "Zha J."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/pages | "147110"xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/title | "Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://purl.uniprot.org/core/volume | "856"xsd:string |
| http://purl.uniprot.org/citations/36543308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36543308 |
| http://purl.uniprot.org/citations/36543308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36543308 |
| http://purl.uniprot.org/uniprot/#_A8KAP0-mappedCitation-36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36543308 |
| http://purl.uniprot.org/uniprot/#_P55199-mappedCitation-36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36543308 |
| http://purl.uniprot.org/uniprot/#_Q75MS0-mappedCitation-36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36543308 |
| http://purl.uniprot.org/uniprot/#_Q59HG4-mappedCitation-36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36543308 |
| http://purl.uniprot.org/uniprot/#_U3KQ90-mappedCitation-36543308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36543308 |