| http://purl.uniprot.org/citations/36547594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36547594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36547594 | http://www.w3.org/2000/01/rdf-schema#comment | "The predominant nematode-trapping fungus Arthrobotrys oligospora harbors a unique polyketide synthase-prenyltransferase (PKS-PTS) gene cluster AOL_s00215g responsible for the biosynthesis of sesquiterpenyl epoxy-cyclohexenoids (SECs) that are involved in the regulation of fungal growth, adhesive trap formation, antibacterial activity, and soil colonization. However, the function of one rare gene (AOL_s00215g275 (275)) embedded in the cluster has remained cryptic. Here, we constructed two mutants with the disruption of 275 and the overexpression of 275, respectively, and compared their fungal growth, morphology, resistance to chemical stress, nematicidal activity, transcriptomic and metabolic profiles, and infrastructures, together with binding affinity analysis. Both mutants displayed distinct differences in their TCA cycles, SEC biosynthesis, and endocytosis, combined with abnormal mitochondria, vacuoles, septa formation, and decreased nematicidal activity. Our results suggest that gene 275 might function as a separator and as an integrated gene with multiple potential functions related to three distinct genes encoding the retinoic acid induced-1, cortactin, and vacuolar iron transporter 1 proteins in this nematode-trapping fungus. Our unexpected findings provide insight into the intriguing organization and functions of a rare non-biosynthetic gene in a biosynthetic gene cluster."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.org/dc/terms/identifier | "doi:10.3390/jof8121261"xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.org/dc/terms/identifier | "doi:10.3390/jof8121261"xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Zhang L.L."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Zhang L.L."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Cheng Q.Y."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Cheng Q.Y."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "He Z.Q."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "He Z.Q."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Li S.H."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Li S.H."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Niu X.M."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Niu X.M."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Wu Q.F."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Wu Q.F."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Yan J.X."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Yan J.X."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Yue X.T."xsd:string |
| http://purl.uniprot.org/citations/36547594 | http://purl.uniprot.org/core/author | "Yue X.T."xsd:string |