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http://purl.uniprot.org/citations/36578534http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36578534http://www.w3.org/2000/01/rdf-schema#comment"Depression, one of the most common causes of disability, has a high prevalence rate in patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for depression. However, the molecular mechanism coupling diabetes to depressive disorder remains largely unknown. Here we found that the neuroinflammation, associated with high-fat diet (HFD)-induced diabetes and obesity, activated the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) in hippocampal neurons. This factor repressed brain-derived neurotrophic factor (BDNF) expression and caused depression-like behaviors in male mice. Besides, the loss of C/EBPβ expression in C/EBPβ heterozygous knockout male mice attenuated HFD-induced depression-like behaviors, whereas Thy1-C/EBPβ transgenic male mice (overexpressing C/EBPβ) showed depressive behaviors after a short-term HFD. Furthermore, HFD impaired synaptic plasticity and decreased surface expression of glutamate receptors in the hippocampus of wild-type (WT) mice, but not in C/EBPβ heterozygous knockout mice. Remarkably, the anti-inflammatory drug aspirin strongly alleviated HFD-elicited depression-like behaviors in neuronal C/EBPβ transgenic mice. Finally, the genetic delivery of BDNF or the pharmacological activation of the BDNF/TrkB signaling pathway by 7,8-dihydroxyflavone reversed anhedonia in a series of behavioral tests on HFD-fed C/EBPβ transgenic mice. Therefore, our findings aim to demonstrate that the inflammation-activated neuronal C/EBPβ promotes HFD-induced depression by diminishing BDNF expression."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.org/dc/terms/identifier"doi:10.3389/fnmol.2022.1068164"xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Gao D."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Chen H."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Huang L."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Fan M."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Gao F."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Liu S."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Wang C."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Wang J.'"xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Xiao X."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Wang Z.H."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Xiong J."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Niu X."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/author"Qin D."xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/date"2022"xsd:gYear
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/name"Front Mol Neurosci"xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/pages"1068164"xsd:string
http://purl.uniprot.org/citations/36578534http://purl.uniprot.org/core/title"Inflammation-activated C/EBPbeta mediates high-fat diet-induced depression-like behaviors in mice."xsd:string