| http://purl.uniprot.org/citations/36594089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36594089 | http://www.w3.org/2000/01/rdf-schema#comment | "The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pro-inflammatory immune receptor potentiating acute lung injury (ALI). However, the mechanism of TREM-1-triggered inflammation response remains poorly understood. Here, we showed that TREM-1 blocking attenuated NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome activation and glycolysis in LPS-induced ALI mice. Then, we observed that TREM-1 activation enhanced glucose consumption, induced glycolysis, and inhibited oxidative phosphorylation in macrophages. Specifically, inhibition of glycolysis with 2-deoxyglucose diminished NLRP3 inflammasome activation of macrophages triggered by TREM-1. Hypoxia-inducible factor-1α (HIF-1α) is a critical transcriptional regulator of glycolysis. We further found that TREM-1 activation facilitated HIF-1α accumulation and translocation to the nucleus via the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Inhibiting mTOR or HIF-1α also suppressed TREM-1-induced metabolic reprogramming and NLRP3/caspase-1 activation. Overall, the mTOR/HIF-1α/glycolysis pathway is a novel mechanism underlying TREM-1-governed NLRP3 inflammasome activation. Therapeutic targeting of the mTOR/HIF-1α/glycolysis pathway in TREM-1-activated macrophages could be beneficial for treating or preventing inflammatory diseases, such as ALI."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.org/dc/terms/identifier | "doi:10.7150/ijbs.77304"xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Zhang C.Y."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Yang H.H."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Yang J.T."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Zhang Y.F."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Guan C.X."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Duan J.X."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Xiong J.B."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Guan X.X."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/author | "Zhong W.J."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/name | "Int J Biol Sci"xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/pages | "242-257"xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/title | "TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury."xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/36594089 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36594089 |
| http://purl.uniprot.org/citations/36594089 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36594089 |
| http://purl.uniprot.org/uniprot/#_Q14DT9-mappedCitation-36594089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36594089 |
| http://purl.uniprot.org/uniprot/#_Q9JKE2-mappedCitation-36594089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36594089 |
| http://purl.uniprot.org/uniprot/Q9JKE2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36594089 |
| http://purl.uniprot.org/uniprot/Q14DT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/36594089 |