| http://purl.uniprot.org/citations/36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36617174 | http://www.w3.org/2000/01/rdf-schema#comment | "Recurrent pregnancy loss (RPL) is a common pathological problem during pregnancy, and its clinical etiology is complex and unclear. Dysfunction of trophoblasts may cause a series of pregnancy complications, including preeclampsia, fetal growth restriction, and RPL. Recently, lncRNAs have been found to be closely related to the occurrence and regulation of pregnancy-related diseases, but few studies have focused on their role in RPL. In this study, we identified a novel lncRNA BBOX1-AS1 that was significantly upregulated in villous tissues and serum of RPL patients. Functionally, BBOX1-AS1 inhibited proliferation, migration, invasion, tube formation and promoted apoptosis of trophoblast cells. Mechanistically, overexpression of BBOX1-AS1 activated the p38 and JNK MAPK signaling pathways by upregulating GADD45A expression. Further studies indicated that BBOX1-AS1 could increase the stability of GADD45A mRNA by binding hnRNPK and ultimately cause abnormal trophoblast function. Collectively, our study highlights that the BBOX1-AS1/hnRNPK/GADD45A axis plays an important role in trophoblast-induced RPL and that BBOX1-AS1 may serve as a potential target for the diagnosis of RPL."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.org/dc/terms/identifier | "doi:10.1093/biolre/ioad002"xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Mao H."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Wen J."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Yuan C."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/author | "Dong N."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/pages | "408-422"xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/title | "BBOX1-AS1 mediates trophoblast cells dysfunction via regulating hnRNPK/GADD45A axis†."xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/36617174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36617174 |
| http://purl.uniprot.org/citations/36617174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36617174 |
| http://purl.uniprot.org/uniprot/#_B4DFF1-mappedCitation-36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36617174 |
| http://purl.uniprot.org/uniprot/#_B3KU16-mappedCitation-36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36617174 |
| http://purl.uniprot.org/uniprot/#_A5JUZ3-mappedCitation-36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36617174 |
| http://purl.uniprot.org/uniprot/#_B4DUQ1-mappedCitation-36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36617174 |
| http://purl.uniprot.org/uniprot/#_P24522-mappedCitation-36617174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36617174 |