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http://purl.uniprot.org/citations/36618420 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundsIMPDH1, a rate-limiting enzyme in de novos synthesis of guanine nucleotides, plays an essential role in the growth and progression of certain tumors. However, there is still a lack of study on IMPDH1 evaluating its role in the tumor immune microenvironment, the potential mechanisms, and its potential as a promising tumor therapeutic target.MethodsThe Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Genotype-Tissue Expression (GTEx), TIMER2.0, KM-Plotter, University of Alabama at Birmingham Cancer data analysis Portal (UALCAN), cbioportal, The Human Protein Atlas (HPA), and Gene Expression Profiling Interactive Analysis 2 (GEPIA2) were used to perform the systematic analysis of IMPDH1, including mRNA expression, protein expression, prognostic value, Enrichment analysis, DNA methylation, immune cell infiltration in pan-cancer, Then, we conducted qRT-PCR and immunohistochemistry to analyze the expression level of IMPDH1 in cancer tissues and non-cancer tissues of patients with primary hepatocellular carcinoma (HCC), and performed the same verification at cellular level.ResultsWe discovered that IMPDH1 was highly expressed in a variety of tumors and was associated with poor prognosis. IMPDH1 not only had the potential as a tumor prognostic marker and therapeutic target, but also was closely related to immune cells, immune checkpoints and immune-related genes and pathways in the tumor immune microenvironment (TIME). Meanwhile, IMPDH1 expression influenced the efficacy and prognosis of tumor patients treated with immune checkpoint inhibitors.ConclusionsIMPDH1 may be as a potential combined target of immunotherapy."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2022.983490"xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/pages | "983490"xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/title | "IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma."xsd:string |
http://purl.uniprot.org/citations/36618420 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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