| http://purl.uniprot.org/citations/36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36632062 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA-binding protein Pcbp2 is widely expressed in the innate and adaptive immune systems and is essential for mouse development. To determine whether Pcbp2 is required for CD4+ T cell development and function, we derived mice with conditional Pcbp2 deletion in CD4+ T cells and assessed their overall phenotype and proliferative responses to activating stimuli. We found that Pcbp2 is essential for T conventional cell (Tconv) proliferation, working through regulation of co-stimulatory signaling. Pcbp2 deficiency in the CD4+ lineage did not impact Treg abundance in vivo or function in vitro. In addition, our data demonstrate a clear association between Pcbp2 control of Runx1 exon 6 splicing in CD4+ T cells and a specific role for Pcbp2 in the maintenance of peripheral CD4+ lymphocyte population size. Last, we show that Pcbp2 function is required for optimal in vivo Tconv cell activation in a T cell adoptive transfer colitis model system."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2022.105860"xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Nguyen N."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Martinelli M."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Aguilar G."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Wilkins B.J."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Ghanem L.R."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Kromer A."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Beier U.H."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Akimova T."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/author | "Lee D.S.M."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/pages | "105860"xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/title | "The poly(C)-binding protein Pcbp2 is essential for CD4pisup>+pi/sup> T cell activation and proliferation."xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/36632062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36632062 |
| http://purl.uniprot.org/citations/36632062 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHG2-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHI3-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHL8-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHN3-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHP9-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHY9-mappedCitation-36632062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36632062 |