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| http://purl.uniprot.org/citations/36640338 | http://www.w3.org/2000/01/rdf-schema#comment | "The BA.2 sub-lineage of the Omicron (B.1.1.529) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant rapidly supplanted the original BA.1 sub-lineage in early 2022. Both lineages threatened the efficacy of vaccine-elicited antibodies and acquired increased binding to several mammalian ACE2 receptors. Cryoelectron microscopy (cryo-EM) analysis of the BA.2 spike (S) glycoprotein in complex with mouse ACE2 (mACE2) identifies BA.1- and BA.2-mutated residues Q493R, N501Y, and Y505H as complementing non-conserved residues between human and mouse ACE2, rationalizing the enhanced S protein-mACE2 interaction for Omicron variants. Cryo-EM structures of the BA.2 S-human ACE2 complex and of the extensively mutated BA.2 amino-terminal domain (NTD) reveal a dramatic reorganization of the highly antigenic N1 loop into a β-strand, providing an explanation for decreased binding of the BA.2 S protein to antibodies isolated from BA.1-convalescent patients. Our analysis reveals structural mechanisms underlying the antigenic drift in the rapidly evolving Omicron variant landscape."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2022.111964"xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Subramaniam S."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Berezuk A.M."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Mannar D."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Saville J.W."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Tuttle K.S."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Cholak S."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/author | "Vahdatihassani F."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/pages | "111964"xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/title | "Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein."xsd:string |
| http://purl.uniprot.org/citations/36640338 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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