| http://purl.uniprot.org/citations/36642505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36642505 | http://www.w3.org/2000/01/rdf-schema#comment | "Mast cells protect a host from invasion by infectious agents and environmental allergens through activation of innate and adaptive immune receptors, their excessive activation being tightly regulated by inhibitory receptors, such as leukocyte immunoglobulin-like receptor (LILR)B4 (gp49B in mice). However, the regulatory mechanism of LILRB4/gp49B expressed on mast cells remains to be clarified in relation to their recently identified ligand, fibronectin (FN), a direct activator of integrins and an indirect stimulator of high-affinity Fc receptor for IgE (FcεRI). Confocal microscopic analysis suggested that gp49B is spatially close to integrin β1 on non-adhered bone marrow-derived mast cells (BMMCs). Their spatial relatedness increases further at robust focal adhesion sites on cells adhering to immobilized FN. However, the confocal fluorescence signal of the α subunit of FcεRI was found to be correlated to neither gp49B nor integrin β1 on non-adherent and adherent BMMCs. Stimulation of FcεRI with an immobilized antigen caused FcεRIα signals to accumulate in an inside area surrounded by robust focal adhesion with a concomitant slight increase in the signal correlation of FcεRIα and integrin β1, accompanied by a less significant increase of the FcεRIα and gp49 correlation. Thus, activating and inhibitory FN receptors integrin and gp49B, respectively, were co-localized via FN at robust focal adhesion sites on BMMCs, while FcεRI was not close to gp49B spatially."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.org/dc/terms/identifier | "doi:10.1620/tjem.2023.j001"xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/author | "Su M.T."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/author | "Itoi S."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/name | "Tohoku J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/pages | "273-284"xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/title | "LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells."xsd:string |
| http://purl.uniprot.org/citations/36642505 | http://purl.uniprot.org/core/volume | "259"xsd:string |
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