| http://purl.uniprot.org/citations/36647607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36647607 | http://www.w3.org/2000/01/rdf-schema#comment | "Nutrition in early life has profound effects on an organism, altering processes such as organogenesis. However, little is known about how specific nutrients affect neuronal development. Dendrites of class IV dendritic arborization neurons in Drosophila larvae become more complex when the larvae are reared on a low-yeast diet compared to a high-yeast diet. Our systematic search for key nutrients revealed that the neurons increase their dendritic terminal densities in response to a combined deficiency in vitamins, metal ions, and cholesterol. The deficiency of these nutrients upregulates Wingless in a closely located tissue, body wall muscle. Muscle-derived Wingless activates Akt in the neurons through the receptor tyrosine kinase Ror, which promotes the dendrite branching. In larval muscles, the expression of wingless is regulated not only in this key nutrient-dependent manner, but also by the JAK/STAT signaling pathway. Additionally, the low-yeast diet blunts neuronal light responsiveness and light avoidance behavior, which may help larvae optimize their survival strategies under low-nutritional conditions. Together, our studies illustrate how the availability of specific nutrients affects neuronal development through inter-organ signaling."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.79461"xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Hayashi Y."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Usui T."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Hattori Y."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Onodera K."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/author | "Kanaoka Y."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/pages | "e79461"xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/title | "Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons."xsd:string |
| http://purl.uniprot.org/citations/36647607 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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