| http://purl.uniprot.org/citations/36649329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36649329 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of mRNA degradation is critical for a diverse array of cellular processes and developmental cell fate decisions. Many methods for determining mRNA half-lives rely on transcriptional inhibition or metabolic labelling. Here, we use a non-invasive method for estimating half-lives for hundreds of mRNAs in the early Drosophila embryo. This approach uses the intronic and exonic reads from a total RNA-seq time series and Gaussian process regression to model the dynamics of premature and mature mRNAs. We show how regulation of mRNA stability is used to establish a range of mature mRNA dynamics during embryogenesis, despite shared transcription profiles. Using single-molecule imaging, we provide evidence that, for the mRNAs tested, there is a correlation between short half-life and mRNA association with P-bodies. Moreover, we detect an enrichment of mRNA 3' ends in P-bodies in the early embryo, consistent with 5' to 3' degradation occurring in P-bodies for at least a subset of mRNAs. We discuss our findings in relation to recently published data suggesting that the primary function of P-bodies in other biological contexts is mRNA storage."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3001956"xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Rattray M."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Love J.C."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Ashe H.L."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Forbes Beadle L."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Artemev A."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/author | "Shapovalova Y."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/pages | "e3001956"xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/title | "Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5' to 3' degradation."xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/36649329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36649329 |
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