DESCRIBE <http://purl.uniprot.org/citations/36652225>

Subject	Predicate	Object
http://purl.uniprot.org/citations/36652225	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36652225	http://www.w3.org/2000/01/rdf-schema#comment	" Background Granzyme K (GzmK) is a serine protease with minimal presence in healthy tissues while abundant in inflamed tissues. Initially thought to play an exclusive role in immune-mediated cell death, extracellular GzmK can also promote inflammation. Objectives To evaluate the role of GzmK in the pathogenesis of atopic dermatitis (AD), the most common inflammatory skin disease. Methods A panel of human AD and control samples was analysed to determine if GzmK is elevated. Next, to determine a pathological role for GzmK in AD-like skin inflammation, oxazolone-induced dermatitis was induced in GzmK-/- and wild-type (WT) mice. Results In human lesional AD samples, there was an increase in the number of GzmK+ cells compared with healthy controls. GzmK-/-mice exhibited reduced overall disease severity characterized by reductions in scaling, erosions and erythema. Surprisingly, the presence of GzmK did not notably increase the overall pro-inflammatory response or epidermal barrier permeability in WT mice; rather, GzmK impaired angiogenesis, increased microvascular damage and microhaemorrhage. Mechanistically, GzmK contributed to vessel damage through cleavage of syndecan-1, a key structural component of the glycocalyx, which coats the luminal surface of vascular endothelia. Conclusions GzmK may provide a potential therapeutic target for skin conditions associated with persistent inflammation, vasculitis and pathological angiogenesis."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.org/dc/terms/identifier	"doi:10.1093/bjd/ljac017"xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Ramachandran R."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Zhao H."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Bird P."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Granville D.J."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Chandrabalan A."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Turner C.T."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Lima H."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Sehmi R."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Gauvreau G."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Zeglinski M.R."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Richardson K.C."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Pawluk M.A."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/author	"Boivin W."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/date	"2023"xsd:gYear
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/name	"Br J Dermatol"xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/pages	"279-291"xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/title	"Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation."xsd:string
http://purl.uniprot.org/citations/36652225	http://purl.uniprot.org/core/volume	"189"xsd:string
http://purl.uniprot.org/citations/36652225	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/36652225
http://purl.uniprot.org/citations/36652225	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/36652225
http://purl.uniprot.org/uniprot/#_A4FUV8-mappedCitation-36652225	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/36652225
http://purl.uniprot.org/uniprot/#_P49863-mappedCitation-36652225	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/36652225