| http://purl.uniprot.org/citations/36662163 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36662163 | http://www.w3.org/2000/01/rdf-schema#comment | "AimIncreased intestinal and blood-brain barriers (BBB) permeability has been suggested to have a role in autism spectrum disorder (ASD). Claudin-5, claudin-11, occludin, β-catenin, vinculin, and paxillin are crucial components of these barriers. This study assessed concentrations of these molecules in preschool children with ASD.MethodsA total of 80 children with ASD and 40 controls aged 18-60 months were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits.ResultsSerum claudin-11, occludin, and β-catenin levels were significantly higher in the ASD group than in the control group. However, no significant difference for serum claudin-5, vinculin, and paxillin levels was detected between the groups.ConclusionThese findings suggest that claudin-11, occludin, and β-catenin may be involved in the pathogenesis of ASD. These proteins may affect the brain by causing dysregulation in intestinal or blood-brain barrier permeability or with other unknown mechanisms."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.org/dc/terms/identifier | "doi:10.1080/08039488.2023.2168055"xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/author | "Bilgic A."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/author | "Kılınc I."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/author | "Energin V.M."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/author | "Ferahkaya H."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/author | "Karagoz H."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/name | "Nord J Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/pages | "506-511"xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/title | "Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder."xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/36662163 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36662163 |
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