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http://purl.uniprot.org/citations/36662390http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/36662390http://www.w3.org/2000/01/rdf-schema#comment"

Background

Gastroesophageal reflux disease (GERD) is a highly prevalent and troublesome disease. Several differentially expressed microRNAs (miRNAs) have been found in GERD.

Objective

This study was to analyze the correlation of miR-29a-3p expression and CYP2C19 genotypes in exfoliated cells from tongue coating of GERD patients and its prognostic value.

Methods

Tongue coating specimens were collected from 130 GERD patients and 70 healthy volunteers and their clinical baseline information was recorded. miR-29a-3p expression in exfoliated cells from tongue coating was determined via RT-qPCR, and its diagnostic efficiency on GERD was evaluated via receiver operating characteristic curve. CYP2C19 genotypes and their correlation with miR-29a-3p were analyzed via polymerase chain reaction restriction fragment length polymorphism technique. The adverse events of patients were documented via 12-month follow-up. The impact of miR-29a-3p expression on the healing rate of patients was analyzed via Kaplan-Meier method. Qualification of miR-29a-3p as an independent prognostic factor of GERD patients was analyzed via multivariate Cox regression analysis.

Results

miR-29a-3p was highly-expressed in exfoliated cells from tongue coating of GERD patients. miR-29a-3p expression had high specificity and sensitivity in diagnosing GERD. CYP2C19 genotypes in GERD patients comprised rapid metabolizers, intermedia metabolizers, and poor metabolizers. miR-29a-3p expression showed a correlation with CYP2C19 genotypes. Higher miR-29a-3p expression predicted higher cumulative incidences of adverse outcomes. Highly-expressed miR-29a-3p was an independent prognostic factor for adverse outcomes of GERD patients.

Conclusion

High expression of miR-29a-3p aided the diagnosis and predicted poor prognosis of GERD patients."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.org/dc/terms/identifier"doi:10.1007/s13258-022-01347-5"xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Liu W."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Niu L."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Zhu L."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Yang L."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/author"Zhang A."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/date"2023"xsd:gYear
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/name"Genes Genomics"xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/pages"673-680"xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/title"Correlation analysis and prognostic value of miR-29a-3p expression and CYP2C19 genotypes in exfoliated cells from tongue coating of patients with gastroesophageal reflux disease."xsd:string
http://purl.uniprot.org/citations/36662390http://purl.uniprot.org/core/volume"45"xsd:string
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