| http://purl.uniprot.org/citations/36681899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36681899 | http://www.w3.org/2000/01/rdf-schema#comment | "Infection with Helicobacter pylori (H. pylori) is the main risk factor for gastric cancer, a leading cause of cancer-related death worldwide. The oncogenic functions of cyclin-dependent kinase 1 (CDK1) are not fully understood in gastric tumorigenesis. Using public datasets, quantitative real-time PCR, western blot, and immunohistochemical (IHC) analyses, we detect high levels of CDK1 in human and mouse gastric tumors. H. pylori infection induces activation of nuclear factor κB (NF-κB) with a significant increase in CDK1 in in vitro and in vivo models (p < 0.01). We confirm active NF-κB binding sites on the CDK1 promoter sequence. CDK1 phosphorylates and inhibits GSK-3β activity through direct binding with subsequent accumulation and activation of β-catenin. CDK1 silencing or pharmacologic inhibition reverses these effects and impairs tumor organoids and spheroid formation. IHC analysis demonstrates a positive correlation between CDK1 and β-catenin. The results demonstrate a mechanistic link between infection, inflammation, and gastric tumorigenesis where CDK1 plays a critical role."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112005"xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Cao L."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Peng D."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "El-Rifai W."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "McDonald O.G."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Zaika A."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Poveda J."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Soutto M."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Khalafi S."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/author | "Al-Mathkour M."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/pages | "112005"xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/title | "CDK1 bridges NF-kappaB and beta-catenin signaling in response to H. pylori infection in gastric tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/36681899 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36681899 |
| http://purl.uniprot.org/citations/36681899 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36681899 |
| http://purl.uniprot.org/uniprot/#_B1AQ78-mappedCitation-36681899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36681899 |
| http://purl.uniprot.org/uniprot/#_D3Z2T9-mappedCitation-36681899 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36681899 |