| http://purl.uniprot.org/citations/36692218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36692218 | http://www.w3.org/2000/01/rdf-schema#comment | "The first characterised FUSE Binding Protein family member, FUBP1, binds single-stranded DNA to activate MYC transcription. Psi, the sole FUBP protein in Drosophila, binds RNA to regulate P-element and mRNA splicing. Our previous work revealed pro-growth functions for Psi, which depend, in part, on transcriptional activation of Myc. Genome-wide functions for FUBP family proteins in transcriptional control remain obscure. Here, through the first genome-wide binding and expression profiles obtained for a FUBP family protein, we demonstrate that, in addition to being required to activate Myc to promote cell growth, Psi also directly binds and activates stg to couple growth and cell division. Thus, Psi knockdown results in reduced cell division in the wing imaginal disc. In addition to activating these pro-proliferative targets, Psi directly represses transcription of the growth inhibitor tolkin (tok, a metallopeptidase implicated in TGFβ signalling). We further demonstrate tok overexpression inhibits proliferation, while tok loss of function increases mitosis alone and suppresses impaired cell division caused by Psi knockdown. Thus, Psi orchestrates growth through concurrent transcriptional activation of the pro-proliferative genes Myc and stg, in combination with repression of the growth inhibitor tok."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.201563"xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Eyras E."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Nie Z."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Hannan R.D."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Lis J.T."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Marshall O.J."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Quinn L.M."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Zaytseva O."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Levens D.L."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Delandre C."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Mitchell N.C."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Muckle D."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/author | "Werner J.K."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/pages | "dev201563"xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/title | "Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors."xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/36692218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36692218 |
| http://purl.uniprot.org/citations/36692218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/36692218 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI54-mappedCitation-36692218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36692218 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LGP3-mappedCitation-36692218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36692218 |
| http://purl.uniprot.org/uniprot/#_A1ZAK7-mappedCitation-36692218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/36692218 |