| http://purl.uniprot.org/citations/36709425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36709425 | http://www.w3.org/2000/01/rdf-schema#comment | "In proliferating neoplasms, microenvironment-derived selective pressures promote tumor heterogeneity by imparting diverse capacities for growth, differentiation, and invasion. However, what makes a tumor cell respond to signaling cues differently from a normal cell is not well understood. In the Drosophila ovarian follicle cells, apicobasal-polarity loss induces heterogeneous epithelial multilayering. When exacerbated by oncogenic-Notch expression, this multilayer displays an increased consistency in the occurrence of morphologically distinguishable cells adjacent to the polar follicle cells. Polar cells release the Jak/STAT ligand Unpaired (Upd), in response to which neighboring polarity-deficient cells exhibit a precursor-like transcriptomic state. Among the several regulons active in these cells, we could detect and further validate the expression of Snail family transcription factor Escargot (Esg). We also ascertain a similar relationship between Upd and Esg in normally developing ovaries, where establishment of polarity determines early follicular differentiation. Overall, our results indicate that epithelial-cell polarity acts as a gatekeeper against microenvironmental selective pressures that drive heterogeneity."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2023.112061"xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Huang Y.C."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Chatterjee D."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Cong F."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Wang X.F."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Deng W.M."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/author | "Machado Costa C.A."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/pages | "112061"xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/title | "Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model."xsd:string |
| http://purl.uniprot.org/citations/36709425 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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