| http://purl.uniprot.org/citations/36718958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36718958 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim: To evaluate the association between genetic polymorphisms and plasma concentration-to-dose ratio of valproic acid (CDRV) in Chinese epileptic patients. Methods: A total of 46 epileptic patients treated with valproic acid therapy were enrolled. 18 SNPs in nine genes related to valproic acid were directly sequenced with Sanger methods. Results: Patients carrying UGT1A6 heterozygous genotypes had significantly lower CDRV than those carrying the wild-type genotypes. In contrast, patients with the homozygote genotypes of CYP2C9 and ABAT had higher CDRV than those with the wild-type genotypes and patients with the heterozygous genotypes of CYP2C19 had higher CDRV. Conclusion: Detection of genetic polymorphism in these genes might facilitate an appropriate dose of valproic acid for epileptic patients. Further studies with larger cohorts are necessary to underpin these observations."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.org/dc/terms/identifier | "doi:10.2217/pgs-2022-0156"xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "Zhao L.L."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "Zheng X.X."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "Xu S.Q."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "Tang D.Q."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/author | "You Y.X."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/name | "Pharmacogenomics"xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/pages | "153-162"xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/title | "Effects of UGT1A, CYP2C9/19 and ABAT polymorphisms on plasma concentration of valproic acid in Chinese epilepsy patients."xsd:string |
| http://purl.uniprot.org/citations/36718958 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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