| http://purl.uniprot.org/citations/36730613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/36730613 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogenic role of circ_POLA2 has only been explored in lung cancer, whereas the role of which in glioblastoma (GBM) is unclear. Our research explored the involvement of circ_POLA2 in GBM. Circ_POLA2 and phosphatasetensinhomolog (PTEN) mRNA levels in GBM and paired nontumor tissues collected from 58 GBM patients were analyzed by real-time quantitative PCR (RT-qPCR). Circ_POLA2 and PTEN were overexpressed in GBM cells to study their interaction by RT-qPCR and Western blot. The roles of circ_POLA2 and PTEN in regulating GBM cell apoptosis were explored using cell apoptosis assay. Our data revealed that circ_POLA2 was upregulated and PTEN was downregulated in GBM. PTEN showed an inverse correlation to circ_POLA2 across GBM tissues, In GBM cells, circ_POLA2 overexpression decreased PTEN accumulation, but PTEN overexpression failed to significantly affect circ_POLA2 expression. Moreover, PTEN reduced the inhibitory effects of circ_POLA2 on GBM cell apoptosis. Circ_POLA2 is overexpressed in MCL and might promote GBM cell apoptosis through downregulating PTEN."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.org/dc/terms/identifier | "doi:10.1097/cad.0000000000001404"xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Xie F."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Meng X."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/author | "Shang Z."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/date | "2023"xsd:gYear |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/name | "Anticancer Drugs"xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/pages | "652-658"xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/title | "CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma."xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/36730613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/36730613 |
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